This study aims to build on the findings from the Pain and Opioids IN Treatment (POINT) study which was the first Australian study to examine the patterns of prescribing for individual patients, and the outcomes for these patients in the longer term. POINT II aims to shed light on the extent to which patients experience problematic opioid use, some of the precursors and protective factors to problematic use, and the consequences of problematic opioid use resulting from chronic opioid therapy.